谢 曦 女 教授 药理学博士 博士研究生导师

邮箱：xiexi@hainanu.edu.cn

1.教育背景

中山大学药学院本科及硕博连读；

美国加州大学伯克利分校访问学者。

2.教学情况

承担本科生药理学、药理学实验； 研究生高级药理学课程

3.科研情况：

主持国家自然科学基金三项，以第一作者或通讯作者发表SCI论文19篇

4.研究领域：

海洋活性物质药理研究、纤维化疾病药理研究

5.社会兼职：海南省爱护小动物志愿者协会高级顾问

6.代表性项目：

（1）PDE12调控线粒体稳态和线粒体自噬介导口腔黏膜下纤维性变，国家自然科学基金地区基金，32万元

（2）褐藻素通过SIRT1/FoxO3信号通路调控肾脏线粒体自噬进而缓解糖尿病肾脏纤维化，国家自然科学基金地区基金，33万，2020.01-2023.12

（3）细胞缝隙连接蛋白Connexin43通过Nrf2/ARE信号通路介导糖尿病肾脏纤维化的研究，国家自然科学基金青年基金，23万，2015.01-2017.12月

（4）细胞缝隙连接蛋白Connexin43介导糖尿病肾脏纤维化的研究，3万， 2015.01-2016.12

（5）虾青素通过Nrf2/ARE信号通路调控线粒体活性氧产生抗糖尿病肾病机制研究，海南省科协青年科技英才学术创新计划， 10万，2018.05-2020.05

（6）虾青素通过抑制线粒体活性氧产生抗糖尿病肾病的机制研究，海南省科技厅, 8万, 2018.03-2019.12

7.代表性成果：

[1] Jing Peng, Zilue Liu, Qihui Wei, Jinmei Xie, Linlin Chen, Cailian Chen, Yong Zhang, Yunjian Zheng, Yutong Wu, Xi Xie. Astaxanthin regulates mitochondrial homeostasis in oral epithelial cells to alleviate oral submucosal fibrosis. Journal of Functional Foods 142 (2026)107132

[2] Jing Peng, Linlin Chen, Jinmei Xie, Xi Wang, Xuerou Wang, Cailian Chen, Rong Wang, Xi Xie*. EGR1 Regulates PDE12 Mediated Mitochondrial Dysfunction to Induce Oral Mucosal Epithelial Barrier Damage in Oral Submucous Fibrosis. European Journal of Pharmacology.

1023(2026) 178865

[3] Yutong Wu., Cailian Chen, Jinmei Xie, Xi Xie*. Haematococcus pluvialis ameliorates renal fibrosis by restoring mitophagy via PINK1-Parkin-p62-LC3 signaling. npj Sci Food (2026)10:9.

[4] Cailian Chen, Jinmei Xie, Rongrui Zhang, Xiuting Chang, Lin Jin*, Xi Xie*. Fucoxanthin alleviates renal fibrosis in experimental diabetic nephropathy by regulating and improving mitochondrial damage. Journal of Functional Food, 2024, 120, 106361

[5] Qihui Wei, Linlin Chen, Wen Luo, Cailian Chen, Yuqing Shi, Jinmei Xie, Xi Xie*, Hai-Bin Luo*. PDE12 disrupts mitochondrial oxidative phosphorylation and mediates mitochondrial dysfunction to induce oral mucosal epithelial barrier damage in oral submucous fibrosis. European Journal of Pharmacology, 2024, 967: 176353

[6] Shanshan Li, Zeyuan Lin, Haiming Xiao, Zhanchi Xu, Chuting Li, Jingran Zeng, Xi Xie*, Li Deng, Heqing Huang. Fyn deficiency inhibits oxidative stress by decreasing c-Cbl-mediated ubiquitination of Sirt1 to attenuate diabetic renal fibrosis, Metabolism-clinical and experimental. 139 (2023) 155378

[7] Dongxiao Zheng, Linlin Chen, Guoping Li, Lin Jin, Qihui Wei, Zilue Liu, Guanyu Yang, Yuanyuan Li and Xi Xie*, Fucoxanthin Ameliorated Myocardial Fibrosis in STZ-Induced Diabetic Rats and Cell Hypertrophy in HG-Induced H9c2 Cells by Alleviating Oxidative Stress and Restoring Mitophagy. Food & Function, 2022, 13:9559-9575

[8] Guanyu Yang, Qingde Li, Jing Peng , Lin Jin, Xiaoyu Zhu, Dongxiao Zheng, Yingxia Zhang, Rong Wang, Yanting Song, Wenting Hu, Xi Xie*，Fucoxanthin regulates Nrf2 signaling to decrease oxidative stress and improves renal fibrosis depending on Sirt1 in HG-induced GMCs and STZ-induced diabetic rats. European Journal of Pharmacology, 2021, 913: 174629

[9] Lin Jin, Dongxiao Zheng, Guanyu Yang, Wei Li, Huan Yang, Qian Jiang, Yongjun Chen, Yingxia Zhang, Xi Xie*, Tilapia Skin Peptides Ameliorate Diabetic Nephropathy in STZ-Induced Diabetic Rats and HG-Induced GMCs by Improving Mitochondrial Dysfunction. Marine Drugs, 2020, 18, 363

[10] GuanyuYang, Lin Jin, Dongxiao Zheng, Xiaoliang Tang, Junwei Yang, Lingxuan Fan, Xi Xie*, Fucoxanthin Alleviates Oxidative Stress through Akt/Sirt1/FoxO3α Signaling to Inhibit HG‐Induced Renal Fibrosis in GMCs. Marine Drugs, 2019, 17, 702

8.荣誉奖励

海南大学优秀教师，海南大学“十佳好老师”，海南大学优秀研究生导师，互联网+大学生创新创业大赛海南赛区优秀指导教师