宋施豪  男，博士  副研究员  博（硕）士生导师

1.教育背景

2018.6–2020.6:南洋理工大学，理学院，博士联合培养  

2018.9–2021.6: 华南农业大学，植物保护学院，博士  

2021.6–2022.9: 中山大学，药学院（深圳），博士后  

2022.9–至今: 海南大学，药学院，副研究员

2.科研情况

课题组主要围绕病原细菌群体感应、致病性调控机制、病原细菌-噬菌体互作机制以及新型抗菌药物研制等研究。主持国家自然科学基金青年基金项目、海南省重点研发项目、海南省自然科学基金高层次人才项目和博士后面上项目，作为科研骨干参与一项国家重点研发项目。以第一或通讯作者在国际高水平SCI期刊如Nat Commun, ISME J, Acta Pharm Sin B, Cell Rep, PLoS Pathog, CCS Chemistry, Virulence, Mol Plant Pathol, mLife等发表多篇论文，同时已授权多项国家发明专利。

3.研究领域

病原细菌信号调控与致病机理

病原细菌-噬菌体互作机制研究

新型抗菌药物研制及作用机理研究

4.代表性项目

1）海南省重点研发项目，金额99万，主持，2026年，在研。

2）海南省自然科学基金高层次人才项目，金额：10万，主持，2025年，在研。

3）国家自然科学基金青年项目，金额30万，主持，2024年，在研。

4）博士后面上项目，金额：8万，主持，2022年，结题。

5）中央高校基本科研业务费，金额：5万，主持，2022年，结题。

6）国家重点研发专项“变革性技术关键科学问题”—高通量培养筛选鉴定健康相关微生物的关键技术，金额：2374万，课题骨干，2021年，在研。

5.代表性成果

1) Li X, Liu J, Li H, Zhang W, Wei H, Song S*, Chen X*. (2026) Isolation and characterization of a novel phage AbT1 and evaluating its anti-biofilm activity and antibiotic synergy. Molecular Biology Reports 53(1):435.

2) Li H, Zhao W, Li X, Wang X, Wei H, Zhang W, Chen X, Song S*. (2026) A novel Queuovirinae subfamily phage targeting Acinetobacter baumannii: Isolation, characterization, and synergistic lysis system. Microbial Pathogenesis 213:108380.

3) Zhang J^#, Li Y^#, Xue T, Li H, Wei H, Li X, Zhang W, Song S*. (2026) Characterization and antibiofilm efficacy of the Pseudomonas aeruginosa phage HKPH_J3. International Journal of Medical Microbiology 322:151706.

4) Song S^#,*, Liu J#, Wang B, Si Y, Han H, Sun X, Wang M, Cui B, Wu G, Huo Y, Xu L, Gao B, Yang L, Wang X, Zhang LH, Deng Y*. (2025) Cis-2-decenoic acid modulates Pseudomonas aeruginosa virulence through a noncanonical transcriptional regulator. mLife 4(6):625-639.

5) Lu T^#, Han H^#, Wu C^#, Li Q, Hu H, Liu W, Shi D, Chen F, Lan L, Li J*, Song S*, Li B*. (2025) Discovery of a novel polymyxin adjuvant against multidrug-resistant gram-negative bacteria through oxidative stress modulation. Acta Pharmaceutica Sinica B 15(3):1680-1695.

6) Wang B^#, Tan H^#, Sun X^#, Lin Z, Chen X, Han H, Wang M, Wang Z, Chen X*, Deng Y*, Song S*. (2024). Inhibition of Candida albicans virulence by moscatin from Dendrobium nobile lindl. Microbial Pathogenesis 197:107089.

7) Song S^#, Cui B^#, Kong X, Deng Y*. (2024). Protocol to identify the signaling pathways of quorum sensing system in Burkholderia cenocepacia. STAR protocols 5(4):103381.

8) Li X^#, Song S^#, Kong X, Chen X, Zhao Z, Lin Z, Jia Y, Zhang Y, Luo HB, Wang QP, Zhang LH, Qian W, Deng Y*. (2024). Regulation of Burkholderia cenocepacia virulence by the fatty acyl-CoA ligase DsfR as a response regulator of quorum sensing signal. Cell Reports 43(5):114223.

9) Xu Y^#, Song S^#, Duan H, Deng Y*, Liu XW*. (2024). Combatting Pathogenic Bacteria with Synthetic Immunotherapeutics from Chitosan: Antibody Recruiting at Engineered Bacterial Surface with Peptidoglycan Analogs. CCS Chemistry 6:1-10.

10) Li X^#, Yin W^#, Lin JD^#, Zhang Y, Guo Q, Wang G, Chen X, Cui B, Wang M, Chen M, Li P, He YW, Qian W, Luo H, Zhang LH, Liu XW*, Song S*, Deng Y*. (2023). Regulation of the physiology and virulence of Ralstonia solanacearum by the second messenger 2',3'-cyclic guanosine monophosphate. Nature Communications 14(1):7654.

11) Song S^#,*, Zhao S^#, Sun X^#, Meng L, Wang Z, Tan H, Liu J, Zhang M, Deng Y*. (2023). Anti-virulence strategy of diaryl chalcogenide compounds against Candida albicans infection. Virulence 14(1):2265012.

12) Huang J^#, Song S^#,*, Zhao S, Sun X, Wang Z, Huang X, Xiao Q, Deng Y*. (2023). Anti-virulence activity of novel (1-heteroaryloxy-2-hydroxypropyl)-phenylpiperazine derivatives against both wild-type and clinical drug-resistant Candida albicans strains. Microbial Biotechnology 16(1):116-127.

13) Song S, Sun X, Guo Q, Cui B, Zhu Y , Li X, Zhou J, Zhang LH, Deng Y*. (2022). An anthranilic acid-responsive transcriptional regulator controls the physiology and pathogenicity of Ralstonia solanacearum. PLoS Pathogens 18(5): e1010562.

14) Ye P^#, Li X^#, Cui B^#, Song S^#, Shen F, Chen X, Wang G, Zhou X, Deng Y*. (2022). Proline utilization A controls bacterial pathogenicity by sensing its substrate and cofactors. Communications Biology 5:496.

15) Wang M^#, Li X^#, Song S^#, Cui C, Zhang LH, Deng Y*. (2022). The cis-2-dodecenoic acid (BDSF) quorum sensing system in Burkholderia cenocepacia. Applied and Environmental Microbiology 88(4):e0234221.

16) Song S^#, Sun X^#, Meng L, Wu Q, Wang K, and Deng Y*. (2021) Antifungal activity of hypocrellin compounds and their synergistic effects with antimicrobial agents against Candida albicans. Microbial Biotechnology 14(2):430-443.

17) Song S^#, Yin W^#, Sun X, Cui B, Huang L, Li P, Yang L, Zhou J, Deng Y*. (2020) Anthranilic acid from Ralstonia solanacearum plays dual roles in intraspecies signalling and inter-kingdom communication. ISME Journal 14:2248-2260.

18) Shen F^#, Yin W^#, Song S^#, Zhang Z, Ye P, Zhang Y, Zhou J, He F*, Li P*, and Deng Y*. (2020) Ralstonia solanacearum promotes pathogenicity by utilizing L-glutamic acid from host plants. Molecular Plant Pathology 21:1099-1110.

19) Cui C^#, Song S^#, Yang C^#, Sun X, Huang Y, Li K, Zhao S, Zhang Y, and Deng Y*. (2019) Disruption of Quorum Sensing and Virulence in Burkholderia cenocepacia by a Structural Analogue of the cis-2-Dodecenoic Acid Signal. Applied and Environmental Microbiology 85(8):e00105-19.

20) Song S^#, Fu S^#, Sun X^#, Li P, Wu J, Dong T, He F and Deng Y*. (2018) Identification of Cyclic Dipeptides from Escherichia coli as New Antimicrobial Agents against Ralstonia solanacearum. Molecules 23(1):214.

21) Cui C^#, Yang C^#, Song S^#, Fu S, Sun X, Yang L, He F, Zhang LH, Zhang Y, and Deng Y*. (2018) A novel two-component system modulates quorum sensing and pathogenicity in Burkholderia cenocepacia. Molecular Microbiology 108: 32-44.

6.荣誉奖励

深圳市海外高层次C类人才

海南省高层次人才