刘文文 药学博士 副教授 硕士生/博士生导师

邮箱：wenwenliu@hainanu.edu.cn

海南省D类人才

1.教育背景

2016.09-2021.06 华东理工大学 药学专业 博士（硕博连读）

2012.09-2016.06 安徽理工大学 制药工程专业 学士

2.教学情况

《药理学》、《药理学实验》、《抗衰老研究进展·延长生命的奥秘》

3.科研情况

瞄准国家重大需求，面向人民生命健康，致力于衰老（相关疾病）靶标/机制研究与候选新药研发。

（1）基于老药库（化药+中草药）开展抗衰老活性筛选、药效评价、靶标/机制研究和结构优化，已解析10余种老药抗衰老新用途。

（2）综合构建线虫、细胞（肺、肾、皮肤、角膜内皮、血管内皮细胞等）、小鼠（衰老和器官增龄疾病模型）水平的抗衰老研究平台，包含抗衰老表型筛选→活性确证→靶标鉴定与确证→机制通路研究→结构优化→成药性评价，助力衰老及相关疾病干预药物研发。

（3）在Nature Aging、Advanced Science、Journal of Medicinal Chemistry等期刊发表论文20余篇；申请专利15项；主持国自然面上项目、国自然青年科学基金项目、海南省科学基金、横向课题等6项。

4.研究领域

衰老靶标确证和干预药物研发

5.社会兼职

Acta Materia Medica首届青年编委

中国中医药信息学会中医临床药学分会理事

Traditional Medicine Research青年编委

6.代表性项目

[1] 国家自然科学基金委员会，面上项目，2025-01至2028-12，在研，主持

[2] 国家自然科学基金委员会，青年科学基金项目，2023-01至2025-12，在研，主持

7.代表性成果

[1] Sicong Qiao^#, Xin Chen^#, Youyou Chen^#, Yihe Song, Donglei Shi, Zhifan Mao, Jian Li*, Yunyuan Huang*, Wenwen Liu*. Discovery of non-antibacterial enrofloxacin derivatives with emerging anti-aging effects through drug repurposing and secondary development. J. Med. Chem. 2025, 68, 14312−14332. (Front cover article)

[2] Liru Chen^#, Deyan Wu^#, Sen Wang, Lingyu Wu, Youyou Chen, Baoli Li, Haibin Luo*, Jian Li*, Wenwen Liu *. Moracin M derivative targeting PDE4 for the treatment of psoriasis. Acta Mater. Med. 2025, 4, 293−301.

[3] Zhifan Mao^#, Wenwen Liu ^#, Rong Zou^#, Ling Sun^#, Shuman Huang, Lingyu Wu, Liru Chen, Jiale Wu, Shijie Lu, Zhouzhi Song, Xie Li, Yunyuan Huang, Yong Rao, Yi-You Huang, Baoli Li*, Zelan Hu*, Jian Li*. Glibenclamide targets MDH2 to relieve aging phenotypes through metabolism-regulated epigenetic modification. Sig. Trans duct. Target. Ther. 2025, 10, 67.

[4] Jiqun Wang^#, Wenwen Liu^#, Yunyuan Huang^#, Guangwei Wang, Xiaobo Guo, Donglei Shi, Tianyue Sun, Chaojiang Xiao, Chao Zhang, Bei Jiang*, Yuan Guo*, Jian Li*. A senomorphlytic three-drug combination discovered in Salsola collina for delaying aging phenotypes and extending healthspan. Adv. Sci. 2024, 11, 2401862.

[5] Donglei Shi^#, Wenwen Liu ^#, Ying Gao^#, Xinming Li, Yunyuan Huang, Xiaokang Li, Tony D. James, Yuan Guo*, Jian Li*. Photoactivatable senolysis with single-cell resolution delays aging. Nat. Aging 2023, 3, 297–312. (Research Briefing, Nat. Aging 2023, 3, 244–245；News & Views, Nat. Chem. 2023, 15, 451–452)

[6] Jiqun Wang^#, Yunyuan Huang^#, Kaixuan Shi^#, Lingyuan Bao, Chaojiang Xiao, Tianyue Sun, Zhifan Mao, Jiali Feng, Zelan Hu, Zhenghan Guo, Jing Li, Bei Jiang*, Wenwen Liu *, Jian Li*. Nicandra physalodes extract exerts antiaging effects in multiple models and extends the lifespan of Caenorhabditis elegans via DAF-16 and HSF-1. Oxid. Med. Cell. Longev. 2022, 3151071.

[7] Keting Bao^#, Wenwen Liu ^#, Zhouzhi Song^#, Jiali Feng, Zhifan Mao, Lingyuan Bao, Tianyue Sun, Zelan Hu*, Jian Li*. Crotamiton derivative JM03 extends lifespan and improves oxidative and hypertonic stress resistance in Caenorhabditis elegans via inhibiting OSM-9. eLife 2022, 11, e72410.

[8] Zhifan Mao^#, Wenwen Liu ^#, Yunyuan Huang, Tianyue Sun, Keting Bao, Jiali Feng, Alexey Moskalev, Zelan Hu*, Jian Li*. Anti-aging effects of chlorpropamide depend on mitochondrial complex-II and the production of mitochondrial reactive oxygen species. Acta Pharm. Sin. B 2022, 12, 665–677.

[9] Donglei Shi^#, Wenwen Liu ^#, Guangwei Wang, Yuan Guo*, Jian Li*. Small-molecule fluorescence-based probes for aging diagnosis. Acta Mater. Med. 2022, 1, 4–23.

[10] Wenwen Liu ^#, Yunhui Guan^#, Sicong Qiao, Jiqun Wang, Keting Bao, Zhifan Mao, Liang Liao, Alexey Moskalev, Bei Jiang, Jin Zhu, Conglong Xia*, Jian Li*, Zelan Hu*. Antiaging effects of Vicatia thibetica de Boiss root extract on Caenorhabditis elegans and doxorubicin-induced premature aging in adult mice. Oxid. Med. Cell. Longev. 2021, 9942090.

[11] Wenwen Liu ^#, Huiling Lin^#, Zhifan Mao^#, Lanxin Zhang, Keting Bao, Bei Jiang, Conglong Xia, Wenjun Li, Zelan Hu*, Jian Li*. Verapamil extends lifespan in Caenorhabditis elegans by inhibiting calcineurin activity and promoting autophagy. Aging-US 2020, 12, 5300–5317.

[12] Wenwen Liu ^#, Huan Wang^#, Xiaokang Li^#, Yixiang Xu, Jian Zhang, Wei Wang, Qi Gong, Xiaoxia Qiu, Jin Zhu, Fei Mao*, Haiyan Zhang*, Jian Li*. Design, synthesis and evaluation of vilazodone-tacrine hybrids as multitarget-directed ligands against depression with cognitive impairment. Bioorg. Med. Chem. 2018, 26, 3117–3125.

8.荣誉奖励

陕西省高等学校科学技术研究成果奖，分子导向的生物学衰老精准识别与干预，特等，6/6

Acta Materia Medica 2024年优秀审稿人

欢迎具有药学、化学、生物学背景的同学报考本课题组硕士/博士研究生。