石东磊 男 博士 副研究员 博（硕）士生导师

电子邮箱：996476@hainanu.edu.cn; 1119212452@qq.com

2023年7月通过高层次人才引进到海南大学药学院工作。

1.教育背景

2011.09-2015.06 黑龙江大学 制药工程 学士

2016.09-2019.06 西北大学 材料工程 硕士

2020.09-2023.06 华东理工大学 药 学 博士

2.科研情况

研究方向聚焦靶向衰老细胞的诊疗分子开发，研究其在前列腺、皮肤及眼部等器官增龄性疾病中的作用与调控；相关工作以第一作者或通讯作者在Nat. Aging, J. Med. Chem., ACS Sens., Chem. Sci.等期刊发表。主持国家自然科学基金、海南省自然科学基金等项目；参编专著《衰老进程识别与干预》（国家科学技术学术著作出版基金资助）；担任海南省科协智库专家、Aging and Diseases及Acta Materia Medica青年编委；荣获陕西省自然科学二等奖（3/6）、陕西高等学校科学技术研究优秀成果奖（3/6）等。

3.研究领域

药物化学、药物化学生物学—衰老及相关疾病的精准可视化诊疗

4.代表性项目

国家自然科学基金面上基金项目，2027-2030，主持

国家自然科学基金青年基金项目，2025-2027，主持

海南省自然科学基金面上项目，2025-2027，主持

5.代表性成果（2022-2026）

[1] Donglei Shi†; Wenwen Liu†; Ying Gao†; …; Yuan Guo*; Jian Li*, Photoactivatable senolysis with single-cell resolution delays aging, Nat. Aging, 2023, 3, 297-312. (Research Briefing, Nat. Aging, 2023, 3, 244-245；News & Views, Nat. Chem., 2023, 15, 451-452.)

[2] Yangxin Yu†; Xinhang Lv†; Zhuowei Chen†; ...; Jian Li*; Donglei Shi*, Synergistic effects of activatable photodynamic therapy and crisaborole for psoriasis through senolysis and immunomodulation, J. Med. Chem., 2025, 68, 16395-16409.

[3] Xicheng Wang†; Haolan You†; …; Jian Li*; Donglei Shi*; Xiaokang Li*, Development of an Acetaldehyde-Specific Fluorescent Probe: Strategy and Applications, ACS Sens., 2026, https://doi.org/10.1021/acssensors.6c02031.

[4] Xinhang Lv†; Yangxin Yu†; Zhuowei Chen†; ...; Jian Li*; Yuan Guo*; Donglei Shi*, Molecular engineering development of β-galactosidase-activatable fluorogenic probes for precise senescence tracking in cells, tissues and a mouse model of psoriasis, Sens. Actuators B, 2025, 444, 138406.

[5] Xu Qu†, Pengzhao Wu†, Kaixuan Duan†, …, Yuan Guo*, Jianjian Zhang*, Donglei Shi*, Self-calibrating probes constructed on a unique dual-emissive fluorescence platform for the precise tracking of cellular senescence. Chin. Chem. Lett., 2024, 12, 109681.

[6] Xin Chen†; Lingchong He†; Xinhang Lv†; …; Donglei Shi*; Yunyuan Huang*, WDR5-targeted activatable fluorescent probes for tumor-specific imaging in live cells and in vivo, Chin. Chem. Lett., 2025, https://doi.org/10.1016/j.cclet.2025.112300.

[7] Zhuowei Chen†; Zhenqian Chen†; Xinhang Lv†; …; Wenwen Liu*; Donglei Shi*, Highly sensitive β-galactosidase fluorescent probe for tracking senescence with long-term retention via in situ labelling, Dyes Pigm., 2026, 254, 113925.

[8] Yihe Song†; Xinming Li†; Donglei Shi†; …; Yuan Guo*; Jian Li*, A senolysis-based theragnostic prodrug strategy towards chronic renal failure, Chem. Sci., 2022, 13, 11738-11745.

[9] Donglei Shi†; Wenwen Liu†; Guangwei Wang; Yuan Guo*; Jian Li*, Small-molecule fluorescence-based probes for aging diagnosis, Acta Materia Medica, 2022, 1, 4-23

[10] Liangliang Gao; Shuli Pan; Ying Gao; Donglei Shi*; Yuan Guo*, Recent development of organic small-molecule and nanomaterial fluorescent probes for hydrazine, Advanced Agrochem, 2022, 1, 22-38.

欢迎具有药物化学/化学生物学背景的同学报考本课题组