卢 宾  理学博士  副研究员  博（硕）士生导师  电子邮箱：binlu@hainanu.edu.cn

1.教育背景

2023.09-2025.11 南方科技大学化学系，博士后，合作导师：张绪穆 讲席教授

2019.09-2023.06 华中师范大学，化学，博士，导师：陈加荣 教授、肖文精 教授

2016.09-2019.06 华中师范大学，有机化学，硕士，导师：陈加荣 教授、肖文精 教授

2012.09-2016.06 华中师范大学，应用化学，学士，导师：陈加荣 教授

2.科研情况

主要从事抗肿瘤小分子抑制剂的合成与研发，探索作用机制。主持国家自然科学基金青年项目一项、博后面上项目一项。近五年以第一作者或共同第一作者发表论文8篇。

3.研究领域

1）抗肿瘤小分子抑制剂的研发与合成

2）自由基介导的C-C键断裂反应，探索其在药物释放及抗肿瘤中的应用

4.代表性项目

1）青年科学基金项目(C类)：可见光介导非张力C(sp³)-C(sp³)键的还原断裂反应研究，2026-2028，30万，主持，在研；

2）中国博士后科学基金第76批面上资助：烯烃的串联光异构化不对称氢化反应研究，2024-2026, 8万，主持，结题。

5.代表性成果 (^#共同第一作者)

1) Lu, B.^#; Yu, J.^#; Sun, H.; Xiao, R.; Chen, R.; Zhang, X.; Chen, G.-Q.*, Redox-Free and Modular Access to Oxacyclic Phosphines Enabled by a Robust Ambiphilic Phosphine Reagent. CCS Chem. 2025, Just Published. DOI: 10.31635/ccschem.025.202506531.

2) Wang, Y. Z.^#; Lu, B.^#; Chen, G. Q.*; Zhang, X.*, Facile access to chiral anti-1,2-diol derivatives via Ir-catalyzed asymmetric hydrogenation of α-alkoxy-β-ketoesters. Chem. Commun. 2025, 61, 1148-1151.

3) Lu, B.; Yu, J.; Zhang, X.; Chen, G.-Q.*, Recent advances on catalytic asymmetric hydrogenation of oximes and oxime ethers. Tetrahedron Lett. 2024, 136, 154914.

4) Wang, F.^#; Wu, T.^#; Lu, B.^#; Yu, J.; Xiao, R.; Yi, B.; Zhang, X.*; Chen, G.-Q. *, Facile and practical access to chiral benzofused oxa-heterocycles via an asymmetric hydrogenation and intramolecular S_NAr cascade. Org. Chem. Front. 2024, 11, 1118-1123.

5) Lu, B.^#; Bao, F. S.^#; He, Z.-W.; Xiao, W.-J.; Chen, J.-R.*, Visible-Light-Driven Four-Component Radical Relay Aminocarbonylation of Unactivated Alkenes. Chin. J. Chem. 2024, 42, 990-996.

6) Lu, B.; Zhang, Z.; Jiang, M.; Liang, D.; He, Z.-W.; Bao, F.-S.; Xiao, W.-J.; Chen, J.-R.*, Photoinduced Five-Component Radical Relay Aminocarbonylation of Alkenes. Angew. Chem. Int. Ed. 2023, 62, e202309460.

7) Lu, B.; Xu, M.; Qi, X.; Jiang, M.; Xiao, W.-J.*; Chen, J.-R.*, Switchable Radical Carbonylation by Philicity Regulation. J. Am. Chem. Soc. 2022, 144, 14923-14935.

8) Lu, B.; Xiao, W.-J.; Chen, J.-R.*, Recent Advances in Visible-Light-Mediated Amide Synthesis. Molecules 2022, 27, 517.

9) Lu, B.; Cheng, Y.; Chen, L.-Y.; Chen, J.-R.*; Xiao, W.-J., Photoinduced Copper-Catalyzed Radical Aminocarbonylation of Cycloketone Oxime Esters. ACS Catal. 2019, 9, 8159-8164.

10) Lu, B.; Feng, B.; Ye, H.; Chen, J.-R.; Xiao, W.-J.*, Pd/Phosphoramidite Thioether Complex-Catalyzed Asymmetric N-Allylic Alkylation of Hydrazones with Allylic Acetates. Org. Lett. 2018, 20, 3473-3476.