李禄爽 博士 讲师 硕士生导师

邮箱：lvyli@hainanu.edu.cn

1.教育背景

2010.9-2014.6，华中科技大学，药学系，学士

2014.9-2019.6，华中科技大学，药学分析学，博士

2.教学情况

2019.6至今，海南大学药学院。

承担《药物分析学》《高等药物分析》等课程教学。

3.科研情况

高量子产率碳点的制备及其用于四环素类抗生素仪器检测/可视化双模式荧光传感, 海南省自然科学基金高层次人才项目, 主持碳点功能化多孔二氧化硅的制备及其对四环素的检测和去除研究, 海南省自然科学基金青年基金项目, 主持用于药物分析的多孔荧光材料的开发与应用，海南大学科研启动基金项目，主持

4.研究领域

1）药物荧光传感：围绕碳点等新型荧光材料的理性设计与功能化合成，建立面向药物分子及活性代谢物的高灵敏、高特异荧光分析新方法。

2）样品前处理技术：多孔材料及其复合材料，用于复杂生物/环境基质中药物的高效富集、分离与净化，结合色谱-质谱实现痕量精准分析。

5.代表性成果

1) Zongmei Huang, Cong-Ting Wu, Jing Li*, and Lu-Shuang Li*. One-step synthesis of dual-emission carbon dots for ratiometric fluorescence sensing of curcumin in food samples. Microchemical Journal, 2026, 116897.

2) Yuwen Liu, Wen Xu, Jing Li*, and Lu-Shuang Li*. A novel carbon dots pair for the construction of a dual-channel fluorescent sensor array for discrimination and detection of biothiols. Spectrochimica Acta Part A: Molecular and Biomolecular Spectroscopy, 2026, 127255.

3) Feifan Zhou, Yanqiang Shan, Yanjiao Huang, Yuhan Deng, Yingxia Zhang, Wenting Hu, Lu-shuang Li*, Haimei Yang*, Yanting Song*. Covalent Organic Framework Monolith Derived from Thiol–Epoxy Click Chemistry for Evaluating the Blood–Brain Barrier Permeability of Three Flavonoids from Alpiniae oxyphylla fructus. Talanta, 2026, 129834.

4) Yuanxiao Wang, Xueying Chen, Feifan Zhou, Mingyu Pan, Yanjiao Huang, Makoto Tsunoda, Yingxia Zhang, Haimei Yang*, Lu-shuang Li*, Yanting Song*. Bidirectional transport studies of flavonoids from Alpiniae oxyphyllae fructus by in vitro inflammatory blood-brain barrier model combined with UHPLC-MS/MS analysis. Journal of Chromatography B, 2025, 1253, 124471.

5) Jing Li, Su Li, Ya-Lan Duan, Yan-Ting Song, and Lu-Shuang Li*. Oxidant-assisted preparation of carbon dots pairs for construction of a dual-channel fluorescence sensor array for tetracyclines discrimination. Microchemical Journal, 2025, 208, 112372.

6) Lu-Shuang Li, Xiao-Hao Chen, Yu Pei, Xiao-Lin Xie, Cong-Ting Wu, Shuang Cai, Jing Li*, and Wei Gong*. A label-free fluorescence aptasensor for salivary exosomes based on a nano-micro dual-scale signal amplification strategy. Talanta, 2025, 287, 127638.

7) Zongmei Huang, Jing Li, and Lu-Shuang Li*. Ethylenediamine assist preparation of carbon dots with novel biomass for highly sensitive detection of levodopa. RSC Advances, 2025, 15, 420-427.

8) Yiyi Liao, Yuhang Gao, Qigeng Chen, Mingyu Pan, Makoto Tsunoda, Fuping Liu, Yingxia Zhang, Wenting Hu, Lu-shuang Li*, Haimei Yang*, Yanting Song*. Enantioselective toxicity effect and mechanisms of bifenthrin enantiomers on normal human hepatocytes. Food and Chemical Toxicology, 2024, 192, 114952.

9) Lu-Shuang Li, Su Li, Zong-Mei Huang, Yan-Ting Song, Wei Gong, and Jing Li*. Carbon dots-doped melamine–formaldehyde microsphere as a dual functional material for sensing and adsorption of oxytetracycline. Arabian Journal of Chemistry, 2024, 17, 105972.

10) Tongjie Xiao, Mingyu Pan, Yuanxiao Wang, Yanjiao Huang, Makoto Tsunoda, Yingxia Zhang, Rong Wang, Wenting Hu, Haimei Yang*, Lu-Shuang Li*, Yanting Song*. In vitro blood-brain barrier permeability study of four main active ingredients from Alpiniae oxyphyllae fructus. Journal of Pharmaceutical and Biomedical Analysis, 2023, 235, 115637.

11) Lu-Shuang Li, He-Wang Liang, Cong-Ting Wu, Su Li, Ying-Xia Zhang, Yan-Ting Song, Wei Gong*, and Jing Li*. A ratiometric fluorescence sensor for tetracycline detection based on two fluorophores derived from Partridge tea. Microchimica Acta, 2023, 190, 66.

12) Yuhang Gao, Xianglai Liu, Mingyu Pan, Debin Zeng, Xiying Zhou, Makoto Tsunoda, Yingxia Zhang, Xi Xie, Rong Wang, Wenting Hu, Lu-shuang Li*, Haimei Yang*, Yanting Song*. Integrated untargeted fecal metabolomics and gut microbiota strategy for screening potential biomarkers associated with schizophrenia. Journal of Psychiatric Research, 2022, 156, 628-638.

13) Lu-Shuang Li, Yun-Ling Gao, Jia-Li Sun, Long Chen, and Jing Li*. Preparation of thioglycerol-modified silica through thiol-epoxy click reaction and its application in HILIC for detection of oligosaccharide in beverages. Food Chemistry, 2022, 405, 134486.

14) Lu-Shuang Li, Ying-Xia Zhang, Wei Gong*, and Jing Li*. Novel β-cyclodextrin doped carbon dots for host-guest recognition-assisted sensing of isoniazid and cell imaging. RSC Advances, 2022, 12, 30104-30112.

15) Yuge Hou, Xiaofei Jiang, Yuhang Gao, Ying Li, Wensi Huang, Hong Chen, Xiaoyu Tang, Makoto Tsunoda, Jinyu Li, Yingxia Zhang, Xi Xie, Rong Wang, Wenting Hu, Yanting Song*, Lu-shuang Li*. Synthesis of magnetic molecular imprinted polymers for solid-phase extraction coupled with gas chromatography-mass spectrometry for the determination of type II pyrethroid residues in human plasma. Microchemical Journal, 2021, 166, 106232.

16) Xin-Yue Jiao, Lu-shuang Li, Si Qin, Yu Zhang, Kun Huang, Li Xu. The synthesis of fluorescent carbon dots from mango peel and their multiple applications. Colloids and Surfaces A: Physicochemical and Engineering Aspects, 2019, 577, 306-314.

17) Lu-Shuang Li and Li Xu*. Highly fluorescent N,S,P tri-doped carbon dots for Cl- detection and their assistance of TiO2 as the catalyst in the degradation of methylene blue. Journal of Photochemistry and Photobiology A: Chemistry, 2020, 399, 112643.

18) Lu-Shuang Li and Li Xu*. Highly fluorescent silicon quantum dots decorated silica microspheres for selective detection and removal of Au3+ and subsequent catalytic application. Journal of Industrial and Engineering Chemistry, 2020, 84, 375-383.

19) Lu-Shuang Li, Xin-Yue Jiao, Yu Zhang, Cheng Cheng, Kun Huang*, and Li Xu*. Green synthesis of fluorescent carbon dots from Hongcaitai for selective detection of hypochlorite and mercuric ions and cell imaging. Sensors and Actuators B: Chemical, 2018, 263, 426-435.

20) Lu-Shuang Li, Xin-Yue Jiao, Yu Zhang, Cheng Cheng, Kun Huang*, and Li Xu*. Highly fluorescent carbon dots synthesized with binary dopants for “turn off” and “turn off-on” sensing and cell imaging. Sensors and Actuators B: Chemical, 2018, 268, 84-92.