王  阳  理学博士  副研究员 博士生导师 邮箱：wang-yang@hainanu.edu.cn

1.教育背景      

2017.09 - 2021.06 理学博士  有机化学  中山大学

2014.09 - 2017.06 理学硕士  材料化学  福建师范大学 （中科院福建物质结构所联合培养）  

2010.09 - 2014.06 理学学士  材料化学  安阳师范学院  

2.工作经历

2021.8-2024.01  博士后  香港中文大学（深圳）- 附属第二医院（深圳大学联合招聘）

2024.03-至今   海南大学  药学院  副研究员

3.科研情况

基于化学修饰核酸或者核酸的动态结构实现光、小分子和蛋白质等条件响应控制核酸功能，特别是细胞内精准调控基因表达。目前以第一作者（共同第一作者）在Angew. Chem. Int. Ed., Sci. China Chem., CCS Chem., Chem. Sci., Chin. Chem. Lett., Chem. Commun.等化学杂志发表多篇论文。

4.研究领域

致力于开发和应用化学工具研究和调控核酸的结构与功能，以化学手段精准控制功能核酸在细胞中发挥作用。

5.代表性项目

国家自然科学基金青年项目，22307107, 基于化学修饰核酸实现光正交策略多重控制表达，2024-01-01至2026-12-31，30万元，主持。

6.代表性成果（#共同一作）

1) Yang Wang, Qiu-Long Zhang, Yan Liu, Liang-Liang Wang, Wu, Chao-Qun Wu, Ming Shao, Juan Du*, Xiwen Xing* and Liang Xu*. Photo-controllable Multiple and Orthogonal Regulation of Gene Expression by Chemically Modified Oligonucleotides. Sci. China Chem. 2024, 68, 694-704. (IF:10.4).

2)Yang Wang, Chao-Qun Wu, Qiu-Long Zhang, Ming Shao, Yan Liu, Liang-Liang Wang, Zun-Yun Wang, Juan Du*, and Liang Xu*. Switching On/Off of Guide RNA by Photo-Induced Strand Displacement for Functional Control of CRISPR/Cas9. CCS Chem. 2024. 6, 1338-1351. (IF:11.2).

3)Yang Wang, Yan Liu, Fan Xie, Jiao Lin and Liang Xu*, Photocontrol of CRISPR/Cas9 function by sitespecific chemical modification of guide RNA, Chemical Science, 2020. (IF:9.6)

4)Yan Liu^#, Yang Wang^#, Jiayi Zhu, Xuxian Su, Xudong Lin, Liang Xu* and Xiwen Xing*. Employing pH-responsive RNA triplex to control CRISPR/Cas9-mediated gene manipulation in mammalian cells. Chin. Chem. Lett, 2023. (IF:9.1)

5)Qiu-Long Zhang#, Yang Wang#, Liang-Liang Wang#, Fan Xie, Ruo-Yue Wu, Xu-Yang Ma, Han Li, Yan Liu, Shunchun Yao and Liang Xu*. Programming non-nucleic acid molecules into computational nucleic acid systems. Angew. Chem. Int. Ed. 2022. (IF:16.8)

6)Yan Liu#, Yang Wang#, Jiao Lin and Liang Xu*, Theophylline-induced synergic activation of guide RNA to control CRISPR/Cas9 function, Chemmical Communications, 2021. (IF:6.0)

7)Yang Wang, Yan Liu, Liang-Liang Wang, Qiu-Long Zhang*, and Liang Xu* Integrating ligands into nucleic acid systems. ChemBioChem, 2023. (IF:3.2)

8)Yang Wang, Xiaofeng Zhang, Haixiong Liu, Hui Chen and Deguang Huang*. Nickel-Catalyzed Direct Formation of C-S Bond of Aryl Sulfides from Arylsulfonyl Chlorides and Aryl Iodides Using Mn as a Reducing Agent. Org. Chem. Front. 2017. (IF:5.4)

9)Yang Wang#, Haixiong Liu#, Xiaofeng Zhang, Zilong Zhang and Deguang Huang*. Experimental and mechanistic insights into copper (II)-dioxygen catalyzed oxidative N-dealkylation of N-(2-pyridylmethyl) phenylamine and its derivatives. Org. Biomol. Chem. 2017, 15, 9164. (IF:3.6)