杨海梅 博士 副教授 博（硕）士生导师 邮箱：haimeiy@hainanu.edu.cn

1.教育背景

重庆大学 化学工程与技术 博士（硕博连读）

贵州大学 制药工程 学士

2.教学情况

本科生专业课程：药物分析学、药物分析实验

研究生专业课程：现代药物分析选论、仪器分析

3.科研情况

课题围绕光学成像分析开展研究工作，主要包括（1）新型光学探针在生化药物分析中的应用。（2）分子探针、纳米探针、阵列传感模式识别和时间分辨检测领域。主持国家自然科学基金青年C类项目、海南省自然科学基金青年项目等。以第一作者或共同通讯作者发表SCI论文数篇。授权国内发明专利1项目。

4.研究领域

荧光成像和药物筛选

5.代表性项目

[1] 国家自然科学基金青年C类项目，2026-01至2028-12，在研，主持

[2] 海南省自然科学基金青年项目，2025-03至2027-02，在研，主持

6.代表性成果

[1] Jianan Huang, Xianlin He, Ruqi Zhang, Zixuan Ding, Yanting Song*, Haimei Yang*. Tetrachromic InP/ZnS quantum dots-based fluorescent sensor arrays for accurate discrimination of multiplex metal ions. Chemical Engineering Science, 2026, 320, 122735.

[2] Zixuan Ding, Xianlin He, Jianan Huang, Ruqi Zhang, Yanting Song*, Haimei Yang*. A turn-on fluorescence probe for rapidly sensing exogenous and endogenous hydrogen peroxide in living cells, Chemistryselect, 2025, 10(5): e202405541.

[3] Yuanxiao Wang, Xueying Chen, Feifan Zhou, Mingyu Pan, Yanjiao Huang, Makoto Tsunoda, Yingxia Zhang, Haimei Yang*, Lushuang Li*, Yanting Song*. Bidirectional transport studies offlavonoids from Alpiniae oxyphyllae fructus by in vitro inflammatory blood–brain barrier model combined with UHPLC-MS/MS analysis, Journal of Chromatography B, 2025, 1253: 124471.

[4] Haimei Yang, Zixuan Ding, Jiayin Du, Xianlin He, Jianan Huang. Optical activity invertible chiral WSe₂ quantum dots as intracellular redox state indicator and regulator, Chemical Engineering Journal, 2024, 485(1): 149839-149850.

[5] Yiyi Liao, Yuhang Gao, Qigeng Chen, Mingyu Pan, Makoto Tsunoda, Fuping Liu, Yingxia Zhang, Wenting Hu, Lu-shuang Li*, Haimei Yang*, Yanting Song*. Enantioselective toxicity effect and mechanisms of bifenthrin enantiomers on normal human hepatocytes. Food and Chemical Toxicology, 2024, 192, 114952.

[6] Tongjie Xiao, Mingyu Pan, Yuanxiao Wang, Yanjiao Huang, Makoto Tsunoda, Yingxia Zhang, Rong Wang, Wenting Hu, Haimei Yang*, Lu-Shuang Li*, Yanting Song*. In vitro blood brain barrier permeability study of four main active ingredients from Alpiniae oxyphyllae fructus, Journal of Pharmaceutical and Biomedical Analysis, 2023, 235: 115637.

[4] Haimei Yang, Qianghong Zhao, Xian Wang, Yu Wu, Yuchen Su, Weili Wei*. Facile and highly selective sensing of hypochlorous acid in aqueous solution and living cells by using asprepared WSe₂ quantum dots, Sensors and Actuators B: Chemical, 2021, 337: 129782-129790.

[7] Xu Jie, Haimei Yang, Yuchen Su, Zhining Xia, Weili Wei*. Time-resolved monitoring of intracellular processes with a cyclical on-off photoswitchable nanoprobe. ACS Sens, 2020, 5, 40.

[8] Xu Jie, Haimei Yang, Min Wang, Yue Zhang, Wei Weili*, Xia Zhining. A peroxisome-inspired chemiluminescent silica nanodevice for the intracellular detection of biomarkers and its application to insulin-sensitizer screening. Angew Chem Inter Ed, 2017, 56, 14596 – 14601.

7.其他

[1] 2025年海南省第四届专业学位研究生优秀教学案例

[2] 第八届/第九届全国医药院校药学/中药学专业大学生实验技能大赛二等奖（本人为指导老师）

欢迎具有药学、化学、生物学背景的同学报考本课题组硕士/博士研究生。