宋施豪  男 博士 副研究员 博（硕）士生导师

  电子邮箱：songsh@hainanu.edu.cn

  1.教育背景

  2018.6–2020.6:南洋理工大学，理学院，博士联合培养  

  2018.9–2021.6: 华南农业大学，植物保护学院，博士  

  2021.6–2022.9: 中山大学，药学院（深圳），博士后  

  2022.9–至今: 海南大学，药学院，副研究员

  2.科研情况

  主持国家自然科学基金青年基金、博士后面上项目和高校基本科研业务费项目，作为科研骨干参与一项国家重点研发计划。以第一作者或通讯作者在国际高水平SCI期刊如Nature Communications, PLOS Pathogens，CCS Chemistry，ISME Journal，Virulence，Molecular Plant Pathology等发表论文13篇（中科院一区7篇），同时已授权国家发明专利16项。

  3.研究领域

病原细菌信号调控与致病机理

病原细菌-宿主互作机制研究

新型抗菌药物研制及作用机理研究

4.代表性项目

1）国家自然科学基金青年项目，金额30万，主持，2024年，在研。

2）博士后面上项目，金额：8万，主持，2022年，结题。

3）中央高校基本科研业务费，金额：5万，主持，2022年，结题。

4）国家重点研发专项“变革性技术关键科学问题”—高通量培养筛选鉴定健康相关微生物的关键技术，金额：2374万，课题骨干，2021年，在研。

5.代表性成果

1) Xu Y^#, Song S^#, Duan H, Deng Y*, Liu XW*. (2024). Combatting Pathogenic Bacteria with Synthetic Immunotherapeutics from Chitosan: Antibody Recruiting at Engineered Bacterial Surface with Peptidoglycan Analogs. CCS Chemistry, 6:1-10. (IF: 11.2, 中科院1区)

2) Li X^#, Yin W^#, Lin JD^#, Zhang Y, Guo Q, Wang G, Chen X, Cui B, Wang M, Chen M, Li P, He YW, Qian W, Luo H, Zhang LH, Liu XW*, Song S*, Deng Y*. (2023). Regulation of the physiology and virulence of Ralstonia solanacearum by the second messenger 2',3'-cyclic guanosine monophosphate. Nature Communications 14(1):7654. (IF: 16.6, 中科院1区)

3) Song S^#,*, Zhao S^#, Sun X^#, Meng L, Wang Z, Tan H, Liu J, Zhang M, Deng Y*. (2023). Anti-virulence strategy of diaryl chalcogenide compounds against Candida albicans infection. Virulence 14(1):2265012. (IF = 5.2, 中科院1区)

4) Huang J^#, Song S^#,*, Zhao S, Sun X, Wang Z, Huang X, Xiao Q, Deng Y*. (2023). Anti-virulence activity of novel (1-heteroaryloxy-2-hydroxypropyl)-phenylpiperazine derivatives against both wild-type and clinical drug-resistant Candida albicans strains. Microbial Biotechnology 16(1):116-127. (IF:5.7, 中科院2区)

5) Song S, Sun X, Guo Q, Cui B, Zhu Y , Li X, Zhou J, Zhang LH, Deng Y*. (2022). An anthranilic acid-responsive transcriptional regulator controls the physiology and pathogenicity of Ralstonia solanacearum. PLoS Pathogens 18(5): e1010562. (IF:6.7, 中科院1区)

6) Ye P^#, Li X^#, Cui B^#, Song S^#, Shen F, Chen X, Wang G, Zhou X, Deng Y*. (2022). Proline utilization A controls bacterial pathogenicity by sensing its substrate and cofactors. Communications Biology 5:496. (IF: 5.9, 中科院1区)

7) Wang M^#, Li X^#, Song S^#, Cui C, Zhang LH, Deng Y*. (2022). The cis-2-dodecenoic acid (BDSF) quorum sensing system in Burkholderia cenocepacia. Applied and Environmental Microbiology 88(4):e0234221. (IF: 4.4, 中科院2区)

8) Song S^#, Sun X^#, Meng L, Wu Q, Wang K, and Deng Y*. (2021) Antifungal activity of hypocrellin compounds and their synergistic effects with antimicrobial agents against Candida albicans. Microbial Biotechnology 14(2):430-443. (IF: 5.7, 中科院2区, Highlight by Microbial Biotechnology 2020, 13, 1702-1704)

9) Song S^#, Yin W^#, Sun X, Cui B, Huang L, Li P, Yang L, Zhou J, Deng Y*. (2020) Anthranilic acid from Ralstonia solanacearum plays dual roles in intraspecies signalling and inter-kingdom communication. ISME Journal 14:2248-2260. (IF: 11.0, 中科院1区)

10) Shen F^#, Yin W^#, Song S^#, Zhang Z, Ye P, Zhang Y, Zhou J, He F*, Li P*, and Deng Y*. (2020) Ralstonia solanacearum promotes pathogenicity by utilizing L-glutamic acid from host plants. Molecular Plant Pathology 21:1099-1110. (IF: 4.9, 中科院1区)

11) Cui C^#, Song S^#, Yang C^#, Sun X, Huang Y, Li K, Zhao S, Zhang Y, and Deng Y*. (2019) Disruption of Quorum Sensing and Virulence in Burkholderia cenocepacia by a Structural Analogue of the cis-2-Dodecenoic Acid Signal. Applied and Environmental Microbiology 85(8):e00105-19. (IF: 4.6, 中科院2区)

12) Song S^#, Fu S^#, Sun X^#, Li P, Wu J, Dong T, He F and Deng Y*. (2018) Identification of Cyclic Dipeptides from Escherichia coli as New Antimicrobial Agents against Ralstonia solanacearum. Molecules 23(1):214. (IF: 4.6, 中科院2区)

13) Cui C^#, Yang C^#, Song S^#, Fu S, Sun X, Yang L, He F, Zhang LH, Zhang Y, and Deng Y*. (2018) A novel two-component system modulates quorum sensing and pathogenicity in Burkholderia cenocepacia. Molecular Microbiology 108: 32-44. (IF: 3.6, 中科院2区)

6.荣誉奖励

深圳市海外高层次C类人才

海南省高层次人才