宋英奇 博士 副教授 硕士生导师

  电子邮箱：996548@hainanu.edu.cn

  1.教育背景

  2020.09-2023.10 澳门大学 生物医药 哲学博士

  2017.09-2020.07 四川大学 药理学专业 理学硕士

  2013.09-2017.07 山西中医药大学 药学专业 理学学士

  2.科研情况

  主要围绕抗肿瘤和抗炎等疾病相关模型开展药物发现、药物设计、靶向蛋白降解、蛋白——蛋白相互作用、诊疗一体化等方向研究，以第一作者或共同第一作者在Chemical Engineering Journal, Medicinal Research Reviews, British Journal of Pharmacology, Journal of Pharmaceutical Analysis, Chinese Chemical Letters, Bioorganic Chemistry等高水平期刊发表多篇SCI论文。

  3.研究领域

1）药物发现：基于高通量筛选技术发现具有抗肿瘤/抗炎活性的药物

2）药物设计：PROTAC药物分子设计和合成新方法研究

4.代表性成果

1）YQ Song^#, KJ Wu^#, ZM Zhang, TM Liu, CN Ko, WG Zhu, DL Ma^*, WH Wang^*, CH Leung^*. Development of a sensitive luminescent probe to uncover new BRD4 inhibitors in living cells. Chemical Engineering Journal. 2023, 463: 142356.（IF = 16.744，中科院1区）

2）YQ Song, GD Li, D Niu, F Chen, SZ Jing, KW Wong, WH Wang^*, CH Leung^*. A robust luminescent assay for screening alkyladenine DNA glycosylase inhibitors to overcome DNA repair and temozolomide drug resistance. Journal of Pharmaceutical Analysis. 2023.（IF = 14.026，中科院1区）

3）YQ Song, GJ Yang^*, DL Ma, WH Wang^*, CH Leung^*. The role and prospect of lysine-specific demethylases in cancer chemoresistance. Medicinal Research Reviews. 2023, 1-32.（IF = 12.388，中科院1区）

4）YQ Song, C Wu, KJ Wu, QB Han, XM Miao, DL Ma^*, CH Leung^*. Ubiquitination Regulators Discovered by Virtual Screening for the Treatment of Cancer. Frontiers in Cell and Developmental Biology. 2021, 9: 665646. （IF = 6.684，中科院2区）

5）ML Guo^#, YQ Song^#, JF Cheng, GQ Dong, Xun Sun^*, CQ Sheng^*. Hydrophobic tagging-induced degradation of NAMPT in leukemia cells. Chinese Chemical Letters, 2023: 109392.（IF = 9.1, 中科院1区）

6）GJ Yang^#, YQ Song^#, WH Wang, QB Han, DL Ma^*, CH Leung^*. An optimized BRD4 inhibitor effectively eliminates NF-κB-driven triple-negative breast cancer cells. Bioorganic Chemistry, 2021, 114: 105158.（IF = 5.307，中科院1区）

7）LT Liu^#, YQ Song^#, XS Chen^#, Y Liu, JJ Zhu, LM Zhou, SJ Xu, LH Wan^*. Morphine‐induced RACK1‐dependent autophagy in immortalized neuronal cell lines. British Journal of Pharmacology, 2020, 177(7): 1609-1621.（IF = 9.473，中科院1区）

8）R Li^#, YQ Song^#, ZN Ji, L Li^*, LM Zhou^*. Pharmacological biotargets and the molecular mechanisms of oxyresveratrol treating colorectal cancer: Network and experimental analyses. Biofactors, 2020, 46(1): 158-167.（IF = 6.438，中科院2区）

9）SS Cheng, GJ Yang, WH Wang, YQ Song, Ko CN, QB Han, DL Ma^* and CH Leung^*. Identification of a cytisine-based EED-EZH2 protein-protein interaction inhibitor against metastasis in triple-negative breast cancer cells. Acta Materia Medica 1, 2, 197-211.

10）HX Xie, LS Yang, Q Hu, YQ Song, XY Wang, LM Zhou^*, LJ Li^*. Effects of inducing apoptosis and inhibiting proliferation of siRNA on polyadenylate‐binding protein‐interacting protein 1 in tongue cell carcinoma. Head & Neck, 2020, 42(12): 3623-3637.

11）R Li, XY Ma, YQ Song, YY Zhang, WB Xiong, L Li^*, LM Zhou^*. Anti‐colorectal cancer targets of resveratrol and biological molecular mechanism: analyses of network pharmacology, human and experimental data. Journal of Cellular Biochemistry, 2019, 120(7): 11265-11273.

12）宋英奇, 马帅静, 晏晓杰,等. 氧化白藜芦醇对肝癌细胞增殖、迁移、侵袭和自噬的研究[J]. 中药药理与临床, 2018, 34(6):46-50.（中文核心）

13）张媛媛, 宋英奇. 文献报告在药理学化疗药理教学中的应用[J]. 四川生理科学杂志, 2018, 40(03):71-73.

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