殷文博 理学博士 副研究员 硕士生导师

邮箱：yinwb@hainanu.edu.cn

1.教育背景与工作经历

2025．01 至今     海南大学    药学院   副研究员

2022．09—2024．12  北京大学     药物化学生物学     博士后

2019．09—2022．06  沈阳药科大学     药物化学       博士学位

2016．09—2019．06  沈阳药科大学     药物化学       硕士学位

2012．09—2016．06  大连医科大学     生物制药       学士学位

2.科研情况

聚焦于肺部疾病与感染性疾病，采用计算机辅助药物设计、基于靶点的药物设计等方法进行药物开发与相关机制研究。近5年在J. Med. Chem, Eur J Med Chem等期刊发表SCI论文30余篇；主持国自然青年基金一项、参与国自然面上项目一项；完成上海医药集团横向一项，所设计并合成分子A17现已与上海济煜医药科技有限公司达成合作。

3.研究领域：药物化学与化学生物学

新型PDE 7抑制剂的开发与机制研究；

抗耐药感染药物开发与机制研究；

新型偶联药物与降解剂开发；

4.社会兼职

Eur J Med Chem（药化1区）、Int. J. Biol. Macromol（化学1区）等期刊审稿人；

中国药学会高级会员，中国化学会会员。

5.代表性项目

1) 国家自然科学基金青年项目C类，82304278，主持；

2）国家自然科学基金面上项目，81872729，参与；

6.代表性成果

1）Sun, Y. X.; Luo, Z. R.; Li, K. J.; Wang, H. J.; Gao, Z. X.; Zhang, J. C.; Liu, R. R.; Liu, R.; Wu, X. D.; Liu, N.; Zhang, H. Y.; Su, X.; Yin, W. B*.; Zhao, D. M*, Cheng, M. S. Design, Synthesis, and Biological Activity Evaluation of Deuterated Diphenyl Azole Alcohol-Based CYP51 Inhibitors. J. Med. Chem. 2025, 68, 11, 12229–12257.

2） Yin, W. B.; Wu, T. X.; Liu, L.; Jiang, H.; Zhang, Y. X.; Cui, H. X.; Sun, Y.; Qin, Q. H.; Sun, Y. X.; Gao, Z. X.; Zhao, L. Y.; Su, X.; Zhao, D. M*.; Cheng, M. S. Species-selective Targeting of Fungal Hsp90: Design, Synthesis, and Evaluation of Novel 4,5-diarylisoxazole Derivatives for the Combination Treatment of Azole-Resistant Candidiasis. J. Med. Chem. 2022, 65, 5539-5564.

3） Yin, W. B.; Liu, L.; Jiang, H.; Wu, T. X., Cui, H. X.; Zhang, Y. X.; Gao, Z. Y.; Sun, Y.; Qin, Q. H.; Zhao, L. Y.; Su, X.; Zhao, D. M*.; Cheng, M. S. Design, synthesis, and evaluation of novel 3-thiophene derivatives as potent antifungal and fungistatic reagents based on a conformational restriction strategy. Eur. J. Med. Chem. 2022, 233, 114195.

4） Yin, W. B.; Cui, H. X.; Jiang, H.; Zhang, Y. X.; Liu, L.; Wu, T. X.; Sun, Y.; Zhao, L. Y.; Su, X.; Zhao, D. M*.; Cheng, M. S. Broadening antifungal spectrum and improving metabolic stablity based on a scaffold strategy: Design, synthesis, and evaluation of novel 4-phenyl-4,5-dihydrooxazole derivatives as potent fungistatic and fungicidal reagents. Eur. J. Med. Chem. 2022, 227, 113955.

5） Yin, W. B.; Zhang, Y. X.; Cui, H. X.; Jiang, H.; Liu, L.; Zheng, Y.; Wu, T. X.; Zhao, L. Y.; Sun, Y.; Su, X.; Li, S.; Zhao, D. M*.; Cheng, M. S. Design, synthesis and evaluation of novel 5-phenylthiophene derivatives as potent fungicidal of Candida albicans and antifungal reagents of fluconazole-resistant fungi. Eur. J. Med. Chem. 2021, 225, 113740.

6）Zhao, L. Y.; Yin, W. B.; Sun, Y.; Sun, N. N.; Tian, L. F.; Zheng, Y.; Zhang, C.; Zhao, S. Z.; Su, X.; Zhao, D. M*.; Cheng, M. S. Improving the metabolic stability of antifungal compounds based on a scaffold hopping strategy: Design, synthesis, and structure-activity relationship studies of dihydrooxazole derivatives. Eur. J. Med. Chem. 2021, 224, 113715.

7）Zhao, L. Y.; Sun, Y.; Yin, W. B.; Tian, L. F.; Sun, N. N.; Zheng, Y.; Zhang, C.; Zhao, S. Z.; Su, X.; Zhao, D. M*.; Cheng, M. S. Design, synthesis, and biological activity evaluation of 2-(benzo[b]thiophen-2-yl)-4-phenyl-4,5-dihydrooxazole derivatives as broad-spectrum antifungal agents. Eur. J. Med. Chem. 2021, 228, 113987.

8） Qin, Q. H.; Wu, T. X.; Yin, W. B.; Sun, Y. X.; Zhang, X. Y.; Wang, R. F.; Guo, J.; Zhao, D. M*.; Cheng, M. S. Discovery of 2,4-diaminopyrimidine derivatives targeting p21-activated kinase 4: Biological evaluation and docking studies. Archiv der Pharmazie. 2020, 353(10), 2000097.

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