石东磊 男 博士 副研究员 博（硕）士生导师

电子邮箱：996476@hainanu.edu.cn; 1119212452@qq.com

2023年7月通过高层次人才引进到海南大学药学院工作。

1.教育背景

2011.09-2015.06 黑龙江大学 制药工程 学士

2016.09-2019.06 西北大学 材料工程 硕士

2020.09-2023.06 华东理工大学 药 学 博士

2. 科研情况

聚焦衰老及相关疾病的精准诊断与治疗前沿，开展衰老进程精准识别探针分子与诊疗一体化药物分子研发。一方面，设计合成衰老进程精准识别探针分子，用以可视化研究衰老发生机制，辅助抗衰老药物研发；设计合成实用型衰老识别探针，构建药物筛选平台，高通量、快捷评价、筛选抗衰老药物。另一方面基于衰老进程发生机制，设计合成诊疗一体化抗衰老药物分子，精准可视化靶向作用于衰老细胞，延缓机体衰老进程、治疗衰老相关疾病。以第一/共一/共通作者身份在Nature Aging、Chemical Science、Journal of Medicinal Chemistry、Sensors and actuators B-Chemical等期刊发表论文12篇，申请发明专利6项。

3.研究领域

衰老及相关疾病的精准可视化诊疗：有机小分子荧光探针/光敏分子、senolytic/senomorphic药物分子和设计合成

4. 代表性项目

国家自然科学基金青年基金项目，2025-2027，主持

海南省自然科学基金面上项目，2025-2027，主持

海南大学科研启动基金项目，2024-2029，主持

5. 代表性成果

[1] Yangxin Yu†; Xinhang Lv†; Zhuowei Chen†; ...; Jian Li*; Donglei Shi*, Synergistic effects of activatable photodynamic therapy and crisaborole for psoriasis through senolysis and immunomodulation, J. Med. Chem., 2025, 68, 16395-16409.

[2] Xinhang Lv†; Yangxin Yu†; Zhuowei Chen†; ...; Jian Li*; Yuan Guo*; Donglei Shi*, Molecular engineering development of β-galactosidase-activatable fluorogenic probes for precise senescence tracking in cells, tissues and a mouse model of psoriasis, Sens. Actuators B, 2025, 444, 138406.

[3] Donglei Shi†; Wenwen Liu†; Ying Gao†; …; Yuan Guo*; Jian Li*, Photoactivatable senolysis with single-cell resolution delays aging, Nat. Aging, 2023, 3, 297-312. (Research Briefing, Nat. Aging, 2023, 3, 244-245；News & Views, Nat. Chem., 2023, 15, 451-452.)

[4] Donglei Shi†; Shuqiang Chen†; Biao Dong†; ...; Yuan Guo*, Evaluation of HOCl-generating anticancer agents by an ultrasensitive dual-mode fluorescent probe, Chem. Sci., 2019, 10, 3715-3722.

[5] Xu Qu†, Pengzhao Wu†, Kaixuan Duan†, …, Yuan Guo*, Jianjian Zhang*, Donglei Shi*, Self-calibrating probes constructed on a unique dual-emissive fluorescence platform for the precise tracking of cellular senescence. Chinese Chem. Lett. 2024, 12, 109681.

[6] Donglei Shi†; Linghao Hu†; Xinming Li†; …; Yuan Guo*, Jian Li*, Lysosomal polarity increases with aging as revealed by a lysosome-targetable near-infrared fluorescent probe, Sens. Actuators B, 2020, 319, 128302.

[7] Donglei Shi†; Wenwen Liu†; Guangwei Wang; Yuan Guo*; Jian Li*, Small-molecule fluorescence-based probes for aging diagnosis, Acta Materia Medica, 2022, 1, 4-23

[8] Jingye Tian†; Donglei Shi†; Yanhui Zhang†; …; Jian Li*; Yuan Guo*, Stress response decay with aging visualized using a dual-channel logic based fluorescent probe, Chem. Sci., 2021, 12, 13483-13491.

[9] Huan Wang†; Donglei Shi†; …; Jian Li; Yuan Guo*, A facile fluorescent probe with a large Stokes shift for sequentially detecting copper and sulfide in 100% aqueous solution and imaging them in living cells, Sens. Actuators B, 2018, 256, 600-608.

[10] Linghao Hu†; Donglei Shi†; Xinming Li†; …; Yuan Guo*; Jian Li*, Curcumin-based polarity fluorescent probes: Design strategy and biological applications, Dyes Pigments, 2020, 177, 108320.

[11] Yihe Song†; Xinming Li†; Donglei Shi†; …; Yuan Guo*; Jian Li*, A senolysis-based theragnostic prodrug strategy towards chronic renal failure, Chem. Sci., 2022, 13, 11738-11745.

[12] Liangliang Gao; Shuli Pan; Ying Gao; Donglei Shi*; Yuan Guo*, Recent development of organic small-molecule and nanomaterial fluorescent probes for hydrazine, Advanced Agrochem, 2022, 1, 22-38.

欢迎具有药物化学/化学生物学背景的同学报考本课题组